Klaus T Wanner Selected Research

GABA Plasma Membrane Transport Proteins

10/2021	Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
1/2021	Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity.
11/2020	Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1.
1/2019	Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4.
2/2015	Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1.
8/2014	First photoswitchable neurotransmitter transporter inhibitor: light-induced control of γ-aminobutyric acid transporter 1 (GAT1) activity in mouse brain.

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Klaus T Wanner Research Topics

Disease

5	Epilepsy (Aura) 10/2021 - 06/2013
4	Nervous System Diseases (Neurological Disorders) 10/2021 - 01/2019
4	Organophosphate Poisoning 01/2019 - 01/2018
3	Neuralgia (Stump Neuralgia) 10/2021 - 02/2020
2	Pain (Aches) 10/2021 - 01/2012
2	Respiratory Insufficiency (Respiratory Failure) 01/2019 - 09/2018
2	Seizures (Absence Seizure) 01/2017 - 08/2014
1	Poisoning 09/2018
1	Paralysis (Palsy) 09/2018
1	Substance-Related Disorders (Drug Abuse) 01/2012
1	Psychotic Disorders (Schizoaffective Disorder) 01/2012
1	Chronic Pain 01/2012
1	Acute Pain 01/2012
1	Sleep Wake Disorders 01/2012

Drug/Important Bio-Agent (IBA)

6	GABA Plasma Membrane Transport ProteinsIBA 10/2021 - 08/2014
5	Pharmaceutical PreparationsIBA 01/2021 - 06/2013
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2021 - 01/2019
3	OximesIBA 11/2020 - 02/2015
3	gamma-Aminobutyric Acid (GABA)IBA 02/2020 - 01/2012
3	MB327IBA 01/2019 - 01/2018
2	Anticonvulsants (Antiepileptic Drugs)IBA 10/2021 - 01/2012
2	Formaldehyde (Formol)FDA Link 10/2021 - 01/2012
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 02/2020
2	nipecotic acidIBA 11/2020 - 06/2013
2	Analgesics (Analgesic Drugs)IBA 02/2020 - 01/2012
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019 - 09/2018
2	Organophosphorus CompoundsIBA 01/2019 - 09/2018
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 09/2018
2	Pentylenetetrazole (Metrazol)IBA 01/2017 - 08/2014
2	Tiagabine (Gabitril)FDA Link 06/2013 - 01/2012
1	Streptozocin (Streptozotocin)FDA Link 01/2021
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2021
1	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 11/2020
1	AldehydesIBA 11/2020
1	Membrane Transport Proteins (Biological Pump)IBA 02/2020
1	Serine (L-Serine)FDA Link 02/2020
1	AcetylcholinesteraseIBA 01/2019
1	Atropine FDA LinkGeneric 09/2018
1	Cholinergic ReceptorsIBA 09/2018
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 09/2018
1	EsterasesIBA 09/2018
1	Cholinergic Agents (Cholinergics)IBA 09/2018
1	SaltsIBA 01/2018
1	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017
1	hydrazine (hydrazine dihydrochloride)IBA 02/2015
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2012
1	compound 18IBA 01/2012
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2012

Therapy/Procedure

2	Therapeutics 01/2021 - 06/2013
2	Drug Therapy (Chemotherapy) 01/2021 - 09/2018